5-Amino-1MQ 50mg x 60 Capsules

Description

DESCRIPTION

5-Amino-1MQ 50mg capsules deliver 5-amino-1-methylquinolinium, a small-molecule research compound studied as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). In laboratory models, NNMT catalyzes the methylation of nicotinamide using S-adenosylmethionine as the methyl donor, a reaction relevant to NAD+ salvage flux and intracellular methylation balance. This material is supplied as 50mg oral-format capsules for in vitro and preclinical research investigating NNMT enzyme kinetics and downstream metabolic intermediates.

RESEARCH AREAS

• NNMT enzymatic inhibition — studied in cell-free assays for substrate-binding kinetics and inhibition constants.
• NAD+ salvage pathway research — investigated in cultured cells for nicotinamide and 1-methylnicotinamide ratio dynamics.
• Cellular methylation balance — characterized for S-adenosylmethionine consumption and methylation-cycle dynamics in metabolic model systems.
• Comparative inhibitor research — profiled alongside other NNMT inhibitor research compounds for selectivity.

WHAT RESEARCHERS LOOK AT

• Dose-response IC50 determination against recombinant NNMT in vitro.
• LC-MS/MS quantification of 1-methylnicotinamide and NAD+ metabolite pools.
• Enzyme-coupled and fluorometric assay readouts of methyltransferase activity.
• Cellular uptake, stability, and off-target methyltransferase selectivity profiling.

QUICK SPECS

• Form: Capsules
• Amount per capsule: 50 mg
• Count: 60 capsules
• Purity: ≥98% (HPLC)
• Identity: MS-verified (per COA)
• Storage: Sealed, cool, dry, protect from light

IDENTITY BASICS

• Type: Small-molecule NNMT inhibitor (quinolinium salt)
• Formula: C10H11N2+ (5-amino-1-methylquinolinium cation)
• Molecular weight: ~159.21 g/mol (cation)
• CAS: 100130-86-1

SELECTED RESEARCH

• PubChem — chemical identity: https://pubchem.ncbi.nlm.nih.gov/#query=5-amino-1-methylquinolinium
• NNMT inhibitor research: https://pubmed.ncbi.nlm.nih.gov/?term=nicotinamide+N-methyltransferase+inhibitor
• NNMT and NAD+ metabolism: https://pubmed.ncbi.nlm.nih.gov/?term=NNMT+NAD+metabolism
• 5-Amino-1MQ NNMT studies: https://pubmed.ncbi.nlm.nih.gov/?term=5-amino-1MQ+NNMT

Researchers studying NAD+ pathway modulators may also reference NAD+ 500mg for comparative metabolism research.

⚠️ DISCLAIMER

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.