5-Amino-1MQ 50mg

Description

DESCRIPTION

5-Amino-1MQ 50mg is a small-molecule quinolinium compound studied in vitro and in animal models as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine to nicotinamide, a reaction that consumes methyl donors and influences cellular NAD+ salvage flux. By occupying the enzyme’s substrate-binding region, 5-Amino-1MQ is used in research settings to probe how modulation of NNMT activity affects intracellular nicotinamide pools, methylation balance, and downstream metabolic signaling in cultured cells and laboratory models.

RESEARCH AREAS

• Selective NNMT enzyme inhibition — characterized in published literature for inhibition constants in vitro.
• NAD+ salvage pathway research — studied in cell culture for effects on intracellular nicotinamide availability.
• Cellular methylation balance — investigated for S-adenosylmethionine consumption and methylation signaling activity.
• Comparative inhibitor research — characterized alongside other NNMT inhibitor research compounds.

WHAT RESEARCHERS LOOK AT

• Enzyme-kinetic assays measuring NNMT inhibition constants (IC50/Ki) in vitro.
• Quantification of 1-methylnicotinamide and NAD+ metabolite levels via LC-MS.
• Dose-response and selectivity profiling against related methyltransferases.
• Cellular uptake and stability characterization in cultured-cell assay systems.

QUICK SPECS

• Form: Lyophilized powder
• Net per vial: 50 mg
• Purity: ≥98% (HPLC)
• Identity: MS-verified (per COA)
• Storage: -20°C, desiccated, protect from light

IDENTITY BASICS

• Type: Small-molecule quinolinium NNMT inhibitor
• Formula: C10H11N2+ (cation)
• Molecular weight: ~159.21 g/mol (cation)
• CAS: 42464-96-0

SELECTED RESEARCH

• PubChem — chemical identity: https://pubchem.ncbi.nlm.nih.gov/#query=5-amino-1-methylquinolinium
• NNMT inhibition research: https://pubmed.ncbi.nlm.nih.gov/?term=NNMT+inhibitor+5-amino-1MQ
• Nicotinamide N-methyltransferase inhibition: https://pubmed.ncbi.nlm.nih.gov/?term=nicotinamide+N-methyltransferase+inhibition
• NNMT and NAD+ salvage metabolism: https://pubmed.ncbi.nlm.nih.gov/?term=NNMT+NAD+salvage+metabolism

Researchers studying NAD+ pathway modulators may also reference NAD+ 500mg for comparative metabolism research.

⚠️ DISCLAIMER

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.