LL-37 5mg

Description

DESCRIPTION

LL-37 5mg is a 37-residue cationic peptide derived from the C-terminal domain of the human cathelicidin precursor protein hCAP18. Its amphipathic α-helical structure positions cationic and hydrophobic residues on opposing faces, a configuration studied for its interaction with anionic microbial membrane components and lipopolysaccharide. In research models, LL-37 is examined for membrane-association behavior, receptor-mediated signaling pathways, and its proposed role as an immunomodulatory mediator within innate-defense systems. This material is provided strictly as a reference compound for in vitro and laboratory investigation.

RESEARCH AREAS

• Cationic peptide–membrane interaction and amphipathic helix formation in model lipid systems
• Lipopolysaccharide binding and neutralization mechanisms in cell-free assays
• Receptor-mediated signaling (e.g., FPR2/formyl peptide receptor) in cultured cell models
• Modulation of innate-immune mediator expression at the transcriptional level

WHAT RESEARCHERS LOOK AT

• Helical content and secondary structure via circular dichroism under varying ionic conditions
• Membrane permeabilization kinetics using dye-leakage and liposome assays
• Binding affinity and stoichiometry against anionic ligands via spectroscopic titration
• Peptide stability and aggregation state across pH and buffer composition

QUICK SPECS

• Form: Lyophilized powder
• Net per vial: 5mg
• Purity: ≥98% (HPLC)
• Identity: Confirmed by mass spectrometry
• Storage: Store at -20°C; protect from light

IDENTITY BASICS

• Type: Cathelicidin-derived antimicrobial peptide (37 residues)
• Sequence/Formula: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES; C₂₀₅H₃₄₀N₆₀O₅₃
• Molecular weight: ~4493.3 g/mol
• CAS: 154947-66-7

SELECTED RESEARCH

• PubMed: LL-37 the C-terminal peptide of human cathelicidin hCAP18
• PubMed: Structure and membrane interaction of LL-37
• PubMed: LL-37 and FPR2 receptor signaling in immune models
• PubChem: Cathelicidin antimicrobial peptide LL-37 record

⚠️ DISCLAIMER

• For laboratory and in vitro research use only.
• Not for human or veterinary use, consumption, or diagnostic application.
• Not a drug, food, or cosmetic; no therapeutic claims are made or implied.
• Handling restricted to qualified research professionals in an appropriate laboratory setting.