ARA-290 16mg

Description

DESCRIPTION

ARA-290 16mg (cibinetide) is an 11-amino-acid linear peptide derived from the helix B domain of erythropoietin (EPO). It is structurally engineered to interact selectively with the innate repair receptor (IRR), a heteromeric complex composed of the EPO receptor subunit and the CD131 (β-common) receptor, while lacking affinity for the classical homodimeric EPO receptor that mediates erythropoiesis. This receptor selectivity makes ARA-290 a frequently referenced model compound in laboratory investigations of EPO-receptor signaling pathways dissociated from red blood cell production.

RESEARCH AREAS

• Innate repair receptor (IRR) binding research — studied for EPOR-CD131 heteromer binding and downstream signal transduction in cell-based models.
• Non-erythropoietic EPO signaling — investigated for erythropoietin receptor pathway activity independent of erythroid receptor activation.
• Cytokine signaling research — characterized for inflammatory mediator modulation in cultured immune and neural cell systems.
• Intracellular signaling pathway research — studied for JAK/STAT and PI3K/Akt cascade activity associated with IRR engagement in vitro.

WHAT RESEARCHERS LOOK AT

• Receptor-binding affinity and selectivity assays comparing IRR versus homodimeric EPOR engagement.
• Dose-response characterization of signaling endpoints in controlled cell culture preparations.
• Peptide stability, solubility, and reconstitution behavior under defined buffer conditions.
• Analytical confirmation of identity and purity via HPLC and mass spectrometry.

QUICK SPECS

• Form: Lyophilized powder
• Net per vial: 16 mg
• Purity: ≥98% (HPLC)
• Identity: MS-verified (per COA)
• Storage: -20°C, protect from light and moisture

IDENTITY BASICS

• Type: Synthetic linear peptide (11 amino acids), non-erythropoietic EPO derivative
• Sequence: pyroGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser; C₅₀H₈₂N₁₈O₂₃
• Molecular weight: ~1257.3 g/mol
• CAS: 1208243-50-8

SELECTED RESEARCH

• Non-erythropoietic EPO-derived peptide research: https://pubmed.ncbi.nlm.nih.gov/18819760/
• ARA-290 innate repair receptor research: https://pubmed.ncbi.nlm.nih.gov/22751828/
• ARA-290 small fiber neuropathy research: https://pubmed.ncbi.nlm.nih.gov/25271759/
• PubChem — chemical identity: https://pubchem.ncbi.nlm.nih.gov/compound/Cibinetide

Researchers studying immune pathway research compounds may also reference Thymosin Alpha 1 10mg for comparative immune signaling research.

⚠️ DISCLAIMER

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.