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HMG (Menotropin) 75 IU

$75.00

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HMG (Human Menopausal Gonadotropin, Menotropin) — combined FSH/LH activity for research.
Lyophilized gonadotropin preparation, 75 IU per vial, ≥98% purity (HPLC).
Studied for FSHR/LHCGR receptor binding and cAMP signaling in research models.
For laboratory research use only — not for human or veterinary use.

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Description

DESCRIPTION

HMG (Menotropin) 75 IU is a purified glycoprotein preparation containing combined follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity. In research models, these gonadotropins bind their cognate G-protein-coupled receptors (FSHR and LHCGR) on gonadal cells, activating the adenylate-cyclase/cAMP–PKA signaling cascade. This receptor engagement is studied for its role in modulating steroidogenic enzyme expression and gametogenic pathways within the hypothalamic-pituitary-gonadal (HPG) axis. HMG serves as a reference ligand for investigating dual FSH/LH receptor signaling dynamics in controlled laboratory systems.

RESEARCH AREAS

FSH receptor (FSHR) binding and cAMP-mediated signal transduction in gonadal cell models
LH/CG receptor (LHCGR) engagement and downstream steroidogenic pathway activation
Dual gonadotropin signaling and HPG-axis feedback regulation in vitro
Glycoprotein hormone structure–activity relationships and receptor-binding kinetics

WHAT RESEARCHERS LOOK AT

Receptor-binding affinity and competitive displacement assays for FSHR/LHCGR
cAMP accumulation and PKA pathway readouts following receptor activation
Lyophilized peptide reconstitution stability and bioactivity retention over time
Comparative FSH:LH activity ratios across preparation lots via in-vitro bioassay

QUICK SPECS

Form: Lyophilized powder
Net per vial: 75 IU
Purity: ≥98% (HPLC)
Identity: Confirmed by bioassay/MS
Storage: Lyophilized at -20°C; reconstituted at 2–8°C

IDENTITY BASICS

Type: Gonadotropin glycoprotein preparation (combined FSH/LH activity)
Sequence/Formula: Heterodimeric glycoproteins (shared α-subunit + hormone-specific β-subunit)
Molecular weight: ~30 kDa per gonadotropin subunit complex
CAS: 9002-68-0

SELECTED RESEARCH

⚠️ DISCLAIMER

For laboratory research use only — not for human or veterinary use.
Not a drug, food, cosmetic, or dietary supplement; not intended to diagnose, treat, cure, or prevent any condition.
Handling restricted to qualified researchers in an appropriate laboratory setting.
Not for diagnostic or therapeutic applications of any kind.