PT-141 (Bremelanotide) 10mg

Description

DESCRIPTION

PT-141 (Bremelanotide) 10mg is a synthetic cyclic heptapeptide and an analog of the melanocortin peptide family. In laboratory research models, it is characterized as a non-selective agonist at melanocortin receptors, with documented binding affinity at the MC1R, MC3R, and MC4R subtypes. Its cyclic structure and N-terminal acetylation are studied as features influencing receptor interaction and metabolic stability relative to linear melanocortin precursors. This material is provided strictly as a reference compound for in vitro and laboratory investigation of melanocortin receptor signaling pathways.

RESEARCH AREAS

• Agonist binding kinetics at melanocortin receptor subtypes (MC1R, MC3R, MC4R)
• Downstream cAMP and G-protein-coupled receptor signaling cascades in cellular models
• Structure–activity relationships of cyclic versus linear melanocortin analogs
• Peptide cyclization and acetylation as determinants of receptor selectivity and stability

WHAT RESEARCHERS LOOK AT

• Receptor binding assays measuring affinity constants across melanocortin subtypes
• Dose-response curves for cAMP accumulation in transfected cell lines
• Chromatographic and mass-spectrometric confirmation of peptide identity and purity
• Stability profiling under varied reconstitution and storage conditions

QUICK SPECS

• Form: Lyophilized powder
• Net per vial: 10 mg
• Purity: ≥98% (HPLC)
• Identity: Confirmed by mass spectrometry
• Storage: Store lyophilized at -20°C; protect from light and moisture

IDENTITY BASICS

• Type: Synthetic cyclic heptapeptide (melanocortin analog)
• Sequence/Formula: Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH; C₅₀H₆₈N₁₄O₁₀
• Molecular weight: ~1025.2 g/mol
• CAS: 189691-06-3

SELECTED RESEARCH

• PubChem: Bremelanotide (CID 9941379)
• PubMed: Melanocortin receptor agonist pharmacology
• PubMed: Cyclic melanocortin analog receptor interactions
• PubMed: Bremelanotide melanocortin receptor signaling

⚠️ DISCLAIMER

• This product is intended strictly for laboratory and in vitro research use only.
• Not for human or veterinary use, consumption, or therapeutic application of any kind.
• Not a drug, food, cosmetic, or dietary supplement; not approved for diagnostic or clinical use.
• Handling is restricted to qualified researchers in an appropriate laboratory setting.