IGF-1LR3 1MG

Description

DESCRIPTION

IGF-1 LR3 1mg (Long R3 Insulin-like Growth Factor-1) is an 83-amino-acid analog of human IGF-1 in which arginine replaces glutamic acid at position 3 and a 13-residue extension is added at the N-terminus. These modifications reduce binding affinity for IGF-binding proteins (IGFBPs) while preserving recognition of the type 1 IGF receptor (IGF-1R). In research models, the peptide is studied as a ligand for IGF-1R signaling and as a tool for examining receptor-mediated tyrosine kinase activation and downstream pathway engagement in vitro. This material is supplied strictly for laboratory research use.

RESEARCH AREAS

• IGF-1 receptor (IGF-1R) binding and tyrosine kinase autophosphorylation mechanisms
• PI3K/Akt and MAPK/ERK pathway activation in cell-culture systems
• Reduced IGFBP affinity as a modifier of ligand availability in vitro
• Comparative receptor-engagement profiling against native IGF-1 in model systems

WHAT RESEARCHERS LOOK AT

• Receptor-binding affinity assays (Kd determination, competitive displacement)
• Phosphorylation immunoblotting of IGF-1R and downstream effectors
• Peptide solubility, reconstitution stability, and aggregation profiling
• Dose-response characterization across cultured cell lines

QUICK SPECS

• Form: Lyophilized powder
• Net per vial: 1mg
• Purity: ≥98% (HPLC)
• Identity: Confirmed by mass spectrometry
• Storage: Store lyophilized at -20°C; protect from light and moisture

IDENTITY BASICS

• Type: Recombinant IGF-1 analog (single-chain polypeptide)
• Sequence/Formula: 83-amino-acid chain; C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular weight: ~9117.6 Da
• CAS: 946870-92-4

SELECTED RESEARCH

• PubChem: IGF-1 LR3 record
• PubMed: Long R3 IGF-1 receptor binding studies
• PubMed: IGF-1 analog IGFBP affinity
• PubMed: IGF-1R PI3K/Akt signaling mechanisms

⚠️ DISCLAIMER

• For laboratory and research use only.
• Not for human or veterinary use, consumption, or therapeutic application.
• Not a drug, food, cosmetic, or dietary supplement; not approved for any use.
• Handling restricted to qualified researchers in an appropriate laboratory setting.